|
KMID : 0370220070510030194
|
|
Yakhak Hoeji
2007 Volume.51 No. 3 p.194 ~ p.198
|
|
|
Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for an Acute Viral Hepatitis Induced by MHV-2 in ICR Mice
|
|
Joo Seong-Soo
Chin Hyouk-Jun
Won Tae-Joon
Jang Su-Kil
Hwang Kwang-Woo
Lee Do-Ik
|
|
|
Abstract
|
|
|
|
The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2 d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p<0.01). Finally, we concluded that those results were probably from the inhibition of viral replication and at least antiproliferative effect on MHV-2.
|
|
|
KEYWORD
|
|
|
MHV-2, dimethyl dicarboxylate, amantadine, HBV, ICR mouse, lamivudine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|